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Objective
Glucagon‐like peptide‐1 receptor agonists (GLP1s) are effective antiobesity drugs and the subject of intense debate around insurance coverage due to the large prevalence of obesity and overweight. The estimation of the budget impact associated with GLP1 insurance coverage requires estimates of GLP1 prices that account for manufacturer discounts. The authors applied a peer‐reviewed method...
Objective
The goal of this study was to investigate associations of reallocations within 24‐h movement profiles and changes in cardiometabolic biomarkers from early to late pregnancy.
Methods
In 137 individuals with prepregnancy overweight/obesity, waking movement was measured using wrist‐worn accelerometers, sleep was self‐reported, and biomarkers were measured in fasting serum samples at 12 and...
Objective
The study objective was to examine associations of relative fat mass (RFM) and BMI with all‐cause mortality in the Dutch general population and to investigate whether additional adjustment for muscle mass strengthened these associations.
Methods
A total of 8433 community‐dwelling adults from the PREVEND general population cohort (1997–1998) were included. Linear regression models were...
Objective
Fetuin B is a steatosis‐responsive hepatokine that causes glucose intolerance in mice, but the underlying mechanisms remain incompletely described. This study aimed to elucidate the mechanisms of action of fetuin B by investigating its putative effects on white adipose tissue metabolism.
Methods
First, fetuin B gene and protein expression was measured in multiple organs in mice and in...
Objective
The aim of this study was to identify the differential metabolic characteristics of children with overweight and obesity and understand their potential mechanism in different age stratifications.
Methods
Four hundred seventy‐three children were recruited and divided into two age stratifications: >4 years (older children) and ≤4 years (younger children), and overweight and obesity were...
Objective
The study's objective was to explore whether early time‐restricted eating (eTRE) and late time‐restricted eating (lTRE) have different impacts on intrahepatic fat and metabolic health among patients with nonalcoholic fatty liver disease (NAFLD).
Methods
This is an 8‐week, randomized, parallel‐arm, open‐label trial. Forty eligible patients were randomly assigned to eTRE (eating between...
Objective
The aim of this study was to examine BMI trajectories from birth throughout childhood, associations with health outcomes at age 13 years, and time frames during which early‐life BMI influenced adolescent health.
Methods
Participants (1902, 44% male) reported perceived stress and psychosomatic symptoms and were examined for waist circumference (WC), systolic blood pressure (SBP), pulse...
Objective
The objective of this study was to examine the hypothesis that abdominal and gluteal adipocyte turnover, lipid dynamics, and fibrogenesis are dysregulated among insulin‐resistant (IR) compared with insulin‐sensitive (IS) adolescents with obesity.
Methods
Seven IS and seven IR adolescents with obesity participated in a 3‐h oral glucose tolerance test and a multi‐section magnetic resonance...
Objective
Studies have consistently shown that African American individuals lose less weight in response to behavioral interventions, but the mechanisms leading to this result have been understudied.
Methods
Data were derived from the PROmoting Successful Weight Loss in Primary CarE in Louisiana (PROPEL) study, which was a cluster‐randomized, two‐arm trial conducted in primary care clinics. In...
Although pediatric growth curves provide clinical utility, using these metrics for within‐person change over time can be misleading. As research is focused on understanding cardiometabolic consequences of weight gain, it is important to use precise metrics to analyze these longitudinal research questions. Despite several foundational recommendations to limit the use of reference pediatric growth...
Objective
Fibroblast activation protein α (FAP) is expressed in normal adipose tissue and related to some pleiotropic metabolic regulators. However, the exact role and mechanism of FAP in obesity and related metabolic disorders are not well understood.
Methods
FAP knockout mice were fed a normal diet or a high‐fat diet (HFD) for 12 weeks. FAP knockout mice or wild‐type mice treated with an FAP...
Objective
The objective of this study was to investigate whether pausing a weight loss program for a defined period of time could enhance weight loss and reduce attrition.
Methods
Five databases and two trial registries were searched from inception to July 2023. Randomized‐controlled trials of adults with overweight and/or obesity were included if they compared planned‐pause interventions with...
Objective
A ketogenic diet (KD) characterized by very low carbohydrate intake and high fat consumption may simultaneously induce weight loss and be cardioprotective. The “thrifty substrate hypothesis” posits that ketone bodies are more energy efficient compared with other cardiac oxidative substrates such as fatty acids. This work aimed to study whether a KD with presumed increased myocardial ketone...
Objective
The objective of this study was to evaluate the relative importance of the basal rate of glucose appearance (Ra) in the circulation and the basal rate of plasma glucose clearance in determining fasting plasma glucose concentration in people with obesity and different fasting glycemic statuses.
Methods
The authors evaluated basal glucose kinetics in 33 lean people with normal fasting glucose...
Objective
Bariatric surgery, a highly effective treatment for obesity and associated comorbidities, may improve cognition and brain volume in parallel with cardiometabolic function. However, some post‐bariatric individuals develop post‐bariatric hypoglycemia (PBH), which can be frequent and severe. The impact of recurrent hypoglycemia on cognition in PBH is unknown. The objective of this study was...
Objective
The study's objective was to examine the percentage of patients with an initial antiobesity medication (AOM) fill who were persistent with AOM at 3, 6, and 12 months and to characterize factors associated with persistence at 12 months.
Methods
This retrospective cohort study used electronic health records from January 2015 to July 2023 in a large health system in Ohio and Florida and...
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